The Laboratory of Vascular Health and Disease

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The Laboratory of
Vascular Health and Disease


Lee Eunhyeong*, Lee EA*, Kang E, Chon H, LIaiqui-Condori M. Park CH, Park BY, Kang NR, Yoo JS, Lee HS, 

Kim HS, Park SH, Choi SW, Vestweber D, Lee JH, Kim P, Sup Lee WSand Kim I#. An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone. Exp Mol Med  2023  55(2): 

470-484. (*co-first authors, #co-corresponding authors)

Park Chan Soon, Kim SH, Yang HY, Kim JH, Schermuly RT, Cho YS, Kang H, Park JH, Lee E, Park HJ, Yang JM, Noh TW, Lee SP, Bae SS, Han J, Ju YS, Park JB# and Kim I#. Sox17 deficiency promotes pulmonary arterial hypertension via HGF/c-Met signaling. Circ Res 2022 131(10): 792-806. (# co-corresponding authors)

Koh Bong Ihn, Lee HJ, Kwak PA, Yang MJ, Kim JH, Kim HS, Koh GY# and Kim I#. VEGFR2 signaling drives meningeal vascular regeneration upon head injury. Nat Comms 2020 11: 3866. (# co-corresponding authors)

Yang Jee Myung, Park CS, Kim SH, Noh TW, Kim JH, Park S, Lee J. Park JR, Yoo D, Jung HH, Takase H, Shima DT, Schwaninger M, Lee S, Kim IK, Lee J, Ji YS, Jon S, Oh WY, Kim P, Uemura A, Ju YS and Kim I. DII4 suppresses transcytosis for arterial blood-retinal barrier homeostasis. Circ Res 2020 126(6): 767-83.

Kim Il-Kug*, Kim Kangsan*, Lee E, Oh DS, Park CS, Park S. Yang JM, Kim JH, Kim HS, Shima DT, Kim JH, Hong SH, Cho YH, Kim YH, Park JB, Koh GY, Ju YS, Lee HK, Lee S#​ and Kim I#. Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality. J Exp Med  2018 215(3): 963-83.

(* co-first authors, # co-corresponding authors)

Kim I and Koh GY. Taking aim at Sox18. eLife 2017 6: e24238.

Kim Kangsan, Kim IK, Yang JM, Lee E, Koh BI, Song S, Park J, Lee S, Choi C, Kim JW, Kubota Y, Koh GY and Kim I. SoxF transcription factors are positive feedback regulators of VEGF signaling. Circ Res 2016 119(7): 839-52.

Lee Seungjoo, Kim IK, Ahn JS, Woo DC, Kim ST, Song S, Koh GY, Kim HS, Jeon BH and Kim I. Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm. Circulation 2015 131(11): 995-1005.

Lee Seung-Hun*, Lee Sungsu*, Yang Hanseul*, Song S, Kim K, Saunders TL, Yoon JK, Koh GY# and Kim I#. Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis. Circ Res 2014 115(2): 215-26.

(* co-first authors, # co-corresponding authors)

Yang Hanseul*, Lee Sungsu*, Lee S, Kim K, Yang Y, Kim JH, Adams RH, Wells JM, Morrison SJ, Koh GY and Kim I. Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest 2013 123(1): 418-31.

(* co-first authors)

Kim I, Saunders TL and Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 2007 130(3): 470-83.